To identify mut-p53 target miRNAs, we silenced mut-p53R280K in MDA-MB-231 breast cancer cells by RNAi and monitored the levels of a panel of miRNAs, previously found overexpressed in solid tumor types at high frequency of missense TP53 mutations19,20 (Supplementary Fig. 1a). The gene discussed is TP53; the disease is breast carcinoma.