We also observed induction of active cancer-associated fibroblasts (CAFs) markers53 including fibronectin, α-SMA, HIF, and YAP in Wi-38 fibroblasts treated with MDA-MB-231 CM, in a mut-p53/miR-30d-dependent manner (Fig. 5j, Supplementary Fig. 8e-g), indicating that this axis causes functional and metabolic activation of CAFs. The gene discussed is ACTA1; the disease is cancer.