CD8A and neoplasm: This notion is supported by the increased frequencies of CD4+ effector cells (Th1, Th2, and Th17) and CD8+ effector cells in TDLNs (Fig. 7), the unique kinetics of plasma IFNγ levels (Fig. 3), and the impaired accumulation of T cells, B cells and NK cells in the lung and tumor (Fig. 8).