The reduced number of CD4 and CD8 T cells in the TDLNs of the AdIL-17A-transduced 4T1 was likely due to enhanced T cell egress following potent immune activation rather than suppression of immune activation since circulating CD4+ and CD8+ T cells, as well as NKp40+ NK cells and CD19+ B cells, were significantly increased in mice receiving AdIL-17A-transduced 4T1 tumor cell compared to the controls (Fig. 8A). This evidence concerns the gene CD4 and neoplasm.