The destruction complex is composed of AXIN, APC (Adenomatous Polyposis Coli Protein), WTX (Wilms tumor suppressor) and two constitutively active kinases (CK1α/δ and GSK3α/β), which associate with β-catenin and promote its polyubiquitination by phosphorylating the degron motif of β-catenin2. The gene discussed is APC; the disease is Wilms tumor.