This observation was further corroborated in two independent breast cancer datasets, in which higher OTULIN levels significantly correlated with short disease-free survival in basal breast cancer patients (GSE21653) (Supplementary Fig. 6P), and poor distant metastasis-free survival in breast cancer patients received chemotherapies (KM plotter, Supplementary Fig. 6Q)42. Here, OTULIN is linked to breast cancer.