GLI1 and medulloblastoma: Vismodegib at 100 nM concentration has shown to impair bone growth in ex-vivo cultured metatarsal bones22 and decrease proliferation of the precursors of cerebellar granule neurons23, while in vivo studies in a model of medulloblastoma have also shown that vismodegib inhibits Gli1 at a IC50 of 165 nM24, a similar range of concentration as used in the present study.