EPN1 and atherosclerosis: Using ApoE-null atherosclerotic mice (ApoE−/−) fed a high cholesterol-high fat western diet (WD) with inducible endothelial-specific deletion of epsins 1 and 2 (EC-iDKO/ApoE−/−), we demonstrated that loss of endothelial epsins prevented atheroma lesion growth in the aorta, suggesting that epsins are important regulators of atherosclerosis (Fig. 5).