ITPR1 and atherosclerosis: To examine whether epsins regulate atherosclerosis progression by controlling IP3R1 degradation in endothelial cells in vivo, we crossed EC-iDKO/ApoE−/− mice with EC-IP3R1fl/+/ApoE−/− mice to genetically eliminate one IP3R1 allele and determine if we could reverse the atheroprotective effect of epsin-deficiency on lesion progression due to a lessening of degradation of IP3R1 in epsin EC-iDKO mice.