Using ApoE-null atherosclerotic mice (ApoE−/−) fed a high cholesterol-high fat western diet (WD) with inducible endothelial-specific deletion of epsins 1 and 2 (EC-iDKO/ApoE−/−), we demonstrated that loss of endothelial epsins prevented atheroma lesion growth in the aorta, suggesting that epsins are important regulators of atherosclerosis (Fig. 5). This evidence concerns the gene APOE and atherosclerosis.