Although the prognosis for patients with mucosal ASCC remains controversial, our review of cases suggests that this variant of cancer is more aggressive and has a poorer prognosis than conventional SCC.[7] Alterations in the expression of molecules such as E-cadherin and B-carotene, which mediate cell–cell and cell–extracellular matrix adhesions, have been associated with acantholysis and the aggressive behavior of ASCCs.[8–10]. The gene discussed is CDH1; the disease is cancer.