Contrary to In-MS plaques, in Ac-MS plaques there was only a slight decrease in Cer level in comparison to the nCNS (Fig. 3F), whereas C16:0-Cer (Fig. 3A), C18:0-Cer (Fig. 3B), and C18:1-Cer subspecies (Fig. 3C) were significantly upregulated, resulting in a significantly increased total Cer level compared with the NI-OND group (Fig. 3F). This evidence concerns the gene CBLN1 and myeloid sarcoma.