The pattern of connectivity changes in C9+ carriers differs from the pattern of sporadic ALS (Agosta et al., 2013, Heimrath et al., 2014, Schulthess et al., 2016), presymptomatic SOD1+ carriers (Menke et al., 2016), and the pattern in C9-negative FTD (Lee et al., 2014). This evidence concerns the gene C9 and amyotrophic lateral sclerosis.