Considering the interaction of TgROP18 with IL20RB occurred at an early infection stage, and the major cytokines strongly induced by T. gondii at this stage are type I cytokines, and not IL-20 subfamily cytokines [22, 40–43], therefore, the existence of a competition between ROP18 and the IL-20 subfamily working on IL-20R is not possible. The gene discussed is IL20; the disease is infection.