In SKOV3 and A2780 cells, ursolic acid enhances S9 phosphorylation of GSK3β and its inactivation, β-catenin stabilization and accumulation and, surprisingly, reduces expression of cell survival signals (c-myc and Bcl-xL) and matrix-metalloproteinase, which in turn facilitates apoptosis and reduces tumor invasiveness [137]. The gene discussed is GSK3B; the disease is neoplasm.