The occurrence of pathological aggregates of proteins including beta-amyloid fragments (Aβ-plaques) in the interneuronal spaces of brain tissue and the increased level of tau- and hyperphosphorylated-tau proteins in the cerebrospinal fluid of AD-affected subjects indicated the relevance of beta-amyloids (Aβ) and tau-protein in the AD development.2 The gene discussed is MAPT; the disease is Alzheimer disease.