HCT116 is a DNA mismatch repair‐deficient cell line resistant to TGF‐β due to biallelic mutational inactivation of TGFBR2 [37] and has been assigned to the poor prognosis ‘mesenchymal’ CRC consensus molecular subtype (CMS) 4 [38]. Here, TGFB1 is linked to colorectal carcinoma.