In addition, a set of fitness genes related to melanoma with undefined roles in melanocyte biology or melanoma pathogenesis was identified, such as MTMR6 and CRTC3. Pharmacological compounds are available that may halt melanoma growth for the products of 12 of the identified fitness genes related to melanoma, including AHR and MDM2 (Table S4). The gene discussed is CRTC3; the disease is melanoma.