APP and early-onset autosomal dominant Alzheimer disease: Met722Lys (NM_000484.4:c.2166T>A, NP_000475.1:p.Met722Lys) causes a novel missense mutation by ATG conversion to AAG at codon position 722 in exon 17 of the APP gene in a Chinese EOFAD pedigree in 2015 (Wang et al., 2015).