SLC5A10 and Hyperglycemia: As already noted, this transporter is of particularly interest in the context of the FDA-approved test to diagnose blood sugar levels in diabetes patients, which measures the plasma level of the metabolite 1,5-AG, since SGLT5 is likely responsible for the reabsorption of 1,5-AG in the proximal tubule of the kidney, and the transport is inhibited by glucose in response to hyperglycemia.