SLC5A2 and diabetes mellitus: v.In addition, it was shown, based on studies with db/db mice with diabetes and high-glucose-cultured porcine PT LLC-PK1 cells in a two-chamber system treated with the SGLT2 inhibitor canagliflozin, that SGLT2 expression was stimulated by basolateral high glucose concentrations through activation of the so-called GLUT2/importin-α1/HNF-1α pathway, while the expression of the NAD+-dependent protein deacetylase SIRT1 decreases, leading to a deficiency of autophagy [179].