These studies linked mutations in HFE (Homeostatic Iron Regulator) [5], transferrin receptor 2 (TFR2) [6], hemojuvelin (HJV) [7], hepcidin (HAMP) [8] and ferroportin (FPN/SLC40A1) [9,10] to different forms of the genetic iron overload disorder, hereditary hemochromatosis (HH). The gene discussed is TFR2; the disease is hereditary hemochromatosis.