The involvement of CXCL8 in tumor progression and angiogenesis were mediated by multifaceted signaling pathways including NF-κB, JNK, PI3K/Akt, p38 MAPK and ERK [25–27], in which ERK signal pathway is a crucial mediator of a variety of cancer cells fates including proliferation, migration and survival. The gene discussed is NFKB1; the disease is cancer.