EGF and neoplasm: In lung cancer, it was suggested that EGF stimulated a significant increase of CXCL8 production in lung cancer cells, and IL-8 production from lung cancer cells could be initiated by their own produced factors, resulting in the recruitment of inflammatory cells in the tumor microenvironment, as well as the formation of inflammatory microenvironment through PI3K/Akt and ERK pathways [28].