CXCL8 and metastatic malignant neoplasm in the lymph nodes: In agreement with this, it was demonstrated that the expression of CXCL8 was significantly increased in tissues with oesophageal squamous cell carcinoma, of which stronger expression of IL-8 predominantly connected with many advanced-stage pathological characteristics, including depth of invasion, lymph node metastasis, pathologic stage, lymphatic invasion and venous invasion [21].