Furthermore, evidence suggests that mGluR5 and the synergistically regulated NMDAR function may be involved in Aβ-mediated pathology and deficits to object recognition memory in Alzheimer’s disease (Alagarsamy et al., 2001; Renner et al., 2010; Hu et al., 2014; Hamilton et al., 2016). This evidence concerns the gene GRM5 and early-onset autosomal dominant Alzheimer disease.