TRPV1 and Anxiety: Indeed, beneficial effects have already been found in a wide range of disorders such as chronic pain, anxiety, epilepsy, and psychosis.2,12,13,14 Cannabidiol is also interesting because it shows low affinity for the cannabinoid G-protein-coupled receptor CB1 but is an agonist of other receptors such as the transient receptor potential cation channel subfamily V member 1 (TRPV1) and the serotonergic 5-HT1A receptor.2,13