G6PD and malaria: The use of dapsone through the antimalarial drug chloroguanil-dapsone-artesunate (not used in malaria treatment anymore but is used for other medical indications). Individual study analysis of phase 3 clinical trials with chloroguanil-dapsone-artesunate did not identify risk of severe haemolysis in G6PD heterozygous females29,30.