Furthermore, the results of a preclinical study that investigated the role of ACE2 in angiotensin (1–7)-induced hypertension and regulation of the RAS system in the kidney of wild type and Ace2 knockout mice revealed some sex differences in rising of mean arterial pressure, binding of glomerular AT1 receptor, and renal protein expression of the neutral endopeptidase neprilysin, suggesting that females may be protected from angiotensin (1–7)-induced hypertension (52). This evidence concerns the gene MME and Hypertension.