In addition, these women could be at risk of developing several disorders associated with being a PM carrier: fragile X-associated premature ovarian insufficiency (FXPOI) (Sullivan et al., 2011), fragile X-associated tremor/ataxia syndrome (FXTAS) (Jacquemont et al., 2003), and the recently described fragile X-associated neuropsychiatric disorders (FXAND) (Hagerman et al., 2018). The gene discussed is PSMB5; the disease is fragile X-associated tremor/ataxia syndrome.