KNG1 and hereditary angioedema: While the physiopathology of HAE has been investigated by measuring the activity of plasma kallikrein (14, 15) and the consumption of high molecular weight kininogen (HK) in patients' blood (15–17), the measurement of BK is more rarely assessed, either under in vitro stimulation or after addition of synthetic kinins (2, 7, 18, 19).