An open-label interventional study (16) suggested that there was a significant improvement in DAS28 (CRP) after VitD (cholecalciferol) supplementation for more than 3 months in patients with active RA and hypovitaminosis D. The authors mainly contrasted the change in DAS28 (CRP) from baseline 3.68 ± 0.93 to 3.08 ± 1.11 at month 3 in patients who received VitD supplementation, without data from patients who did not receive VitD. The gene discussed is CRP; the disease is rickets.