MCT1/4-mediated lactate transport has been shown to serve as a crucial pro-angiogenic factor to mediate tumor-EC metabolic rewiring, angiogenic activity, and tumor progression in multiple cancers, including glioblastoma, renal cancer, colorectal, and breast cancer, which may rely on activation of oncogenic signaling including nuclear factor-κB (NF-κB) and HIF-1α (Miranda-Gonçalves et al., 2017; Rohlenova et al., 2018; Guo et al., 2019). Here, HIF1A is linked to cancer.