In a prostate cancer cell model, tumor-CAF contact triggers a sirtuin 3 -mediated regulation of HIF1 stabilization and glycolytic phenotype to upregulate MCT4 and enhance lactate secretion from CAFs, while prostate cancer cells increase lactate uptake mediated by MCT1 (Fiaschi et al., 2012). The gene discussed is HIF1A; the disease is prostate carcinoma.