PARP2 and cancer: Finally, we identified a series of SNE core genes associated with DNA repair, in which the MUTYH gene and the PARP2 gene have been shown to be closely related to two approved anti-cancer drug mechanisms, Cisplatin and Olaparib (Khrunin et al., 2014; Verhagen et al., 2015), suggesting that these non-specific genes also have the potential to become drug targets.