They reportedly inhibit diet-induced obesity and prevent the development of IR by activating the bile acid receptor (farnesoid × receptor, FXR) and membrane G protein coupled receptor TGR5, indicating their effects on energy homeostasis (Gastaldelli et al., 2010; Gerard and Vidal, 2019). This evidence concerns the gene NR1H4 and obesity due to melanocortin 4 receptor deficiency.