With the impact of gut microbiota it releases inflammatory adipokines, such as fatty acid binding protein 4 (FABP-4), acylation-stimulating protein (ASP), retinol-binding protein 4 (RBP4), lipocalin-2 (LCN2), and chemerin, etc., which are associated with increased inflammation, obesity, insulin resistance, and eventually T2DM (Lee et al., 2019) (Figure 2). This evidence concerns the gene C3 and obesity due to melanocortin 4 receptor deficiency.