PHD inhibition stabilizes the transcription factor HIF1α, increasing invasiveness, angiogenesis and further metabolic changes in tumor cells (98), whereas inhibition of KDMs, which hydroxylate lysine residue on histones, and of TETs, which induce DNA demethylation of CpG islands near gene promoters, prompts complex epigenetic rearrangements in neoplastic cells (Figure 3). Here, HIF1A is linked to neoplasm.