Multivariable Cox proportional hazards regression analysis stratified for MGMT and adjusted for age, KPS, adjuvant chemoradiation, and pre-operative CE tumor volume, identified a residual CE tumor volume of 0–1 cm3 (HR 0.64; 95% CI, 0.46–0.88 p = 0.007), and 1–5 cm3 (HR 0.71; 95% CI, 0.54–0.94; p = 0.016) as being associated with favorable overall survival. Here, MGMT is linked to cholesteryl ester measurement.