Our experiments in BON-1 cells derived from a pancreatic NET revealed significant treatment-related increase in TNFα synthesis paralleled by a significant reduction in IL-6 and IL-10 expression; this cytokine profile reflects the ability of lanreotide to induce a Th1 cytotoxic immune-response (Figures 3A,B). This evidence concerns the gene IL6 and pancreatic neuroendocrine tumor.