The over-activation of the Wnt pathway, the main signaling mechanism in which β-catenin participates, is a characteristic described in many types of cancer, mainly colon, where inactivating mutations in negative regulators such as APC (Adenomatous Polyposis Coli) or β-catenin itself have been detected in most cases (8, 9, 12). The gene discussed is APC; the disease is cancer.