We proposed DANCR specifically sponges miR-125b-5p to derepress the expression of HK2, a direct target of miR-125b-5p in colon cancer, presenting the DANCR/miR-125b-5p/HK2-glycolysis axis as a new therapeutic target for overcoming cisplatin resistance of colon cancer. This evidence concerns the gene HK2 and colonic neoplasm.