To further validate whether the DANCR-regulated HK2 expression could affect the glycolysis rate of colon cancer cells, glucose uptake, and lactate product and glycolysis enzyme expressions were measured in SW480/CDDP R cells with DANCR inhibition alone or DANCR knockdown plus miR-125b-5p inhibition. The gene discussed is HK2; the disease is malignant colon neoplasm.