Three other pathways are also associated with METTL3 upregulation in bladder cancer, including the METTL3 -CDCP1 (CUB Domain Containing Protein 1), METTL3-ITGA6(Integrin Subunit Alpha 6), and METTL3/YTHDF2-SETD7/KLF4(SET Domain Containing Lysine Methyltransferase 7/ Kruppel Like Factor 4) m6A axes. The gene discussed is KLF4; the disease is urinary bladder carcinoma.