Low METTL14 expression in cancer cells leads to high P2RX6 expression via the ATP-P2RX6-Ca2+-p-ERK1/2(Extracellular Regulated protein Kinases 1/2)-MMP9 (Matrix Metallopeptidase 9) signaling pathway, which promotes renal tumor cell metastasis and invasion (Gong et al., 2019). This evidence concerns the gene MMP9 and cancer.