As with METTL3, the VHL-HIF-ZNF217-METTL14 pathway regulates m6A in ccRCC cells via the PI3K/AKT/mTOR and p53 signaling pathways (Li et al., 2017a; Zhou et al., 2019). This evidence concerns the gene METTL14 and nonpapillary renal cell carcinoma.