The VHL-HIF-ZNF217(Von Hippel-Lindau- Hypoxia Inducible Factor- Zinc Finger Protein 217)-METTL3 pathway may be involved in m6A regulation in ccRCC cells by mediating two downstream m6A targets, the PI3K/AKT/mTOR (Phosphatidylinositol 3-Kinase/AKT, also known as Protein Kinase B/mammalian Target of Rapamycin) and p53 signaling pathways (Li et al., 2017a; Zhou et al., 2019). This evidence concerns the gene TP53 and nonpapillary renal cell carcinoma.