Yu demonstrated upregulated CDR1as expression and downregulated miR-7 expression in HCC tissues compared with the adjacent non-tumor tissues (ANTs), and knockdown of CDR1as and overexpression of miR-7 can both suppress HCC cell proliferation and invasion by suppressing the direct target gene CCNE1 and PIK3CD expression [61]. This evidence concerns the gene CCNE1 and hepatocellular carcinoma.