CDR1as expression in Alzheimer's disease (AD) brain tissue is significantly downregulated, and the sponge effects on miR-7 are weakened [38]; therefore, the target genes of miR-7, such as the ubiquitin protein ligase A, are significantly decreased, indicating that the downregulation of CDR1as expression may be related to the occurrence of AD [38]. The gene discussed is UBE2A; the disease is Alzheimer disease.