PRKAA1 and myocardial infarction: Further investigations may focus on 1) identifying the relationship between AMPK concentrations and the incidence and progression of MI, 2) determining how to retain AMPK signaling at appropriate levels to protect against MI, 3) investigating whether the clinical application of therapeutics targeting AMPK has any suboptimum potency, and 4) further studies on other molecules upstream and downstream of AMPK, which may be potential therapeutic targets for MI in the future.