AMPK activation significantly attenuates the JNK/NF-κB signaling cascade and inhibits mRNA and protein levels of pro-inflammatory cytokines, such as TNF-α and IL-6, during hypoxia/reoxygenation in H9c2 cells, suggesting that AMPK may play a protective role in early myocardial ischemia [54]. This evidence concerns the gene PRKAA2 and myocardial ischemia.