Intriguingly, recent studies have shown that sirt3 levels in pancreatic islets are reduced in patients afflicted with type 2 diabetes [129], and sirt3 overexpression in pancreatic β-cells promotes insulin secretion and abrogates endoplasmic reticulum (ER) stress that is connected to β-cell dysfunction and apoptosis [130]. Here, SIRT3 is linked to type 2 diabetes mellitus.