Mechanistically, resveratrol-induced SIRT1 down-regulates p300 through augmentation of its ubiquitination and proteasomal degradation, further indicating the pivotal role of elevated p300 in pathogenesis of cardiomyopathy, the major cause of death of Duchenne muscular dystrophy patients [64]. The gene discussed is SIRT1; the disease is Duchenne muscular dystrophy.