Curcumin mediated inhibition of p300 acetyltransferase activity, decreased GATA4 acetylation and disruption of p300 interaction with GATA4 prevents hypertension- and MI-induced damage of cardiac structure and function as evidenced by improved ejection fraction, fractional shortening, posterior wall thickness, and myocardial fibrosis, without altering blood pressure [61]. Here, EP300 is linked to myocardial infarction.