In a recent report, we have demonstrated that the cell-permeable small molecule L002, a potent and unique inhibitor of p300, prevents hypertension-induced cardiac hypertrophy and cardiac fibrogenesis in a murine model as evidenced by reduction of hypertension-induced heart weight, ventricular wall thickness, and myocardial matrix remodeling or fibrosis [22]. The gene discussed is EP300; the disease is cardiac hypertrophy.