Significantly elevated levels of p300 or its mutant forms are associated with skin, lung, and cardiac fibrosis [20-23]; human failing heart (Ghosh unpublished data); diabetic cardiomyopathy [24]; kidney disease [22,25]; liver disease [26]; metabolic syndrome [27]; senescence and aging [28,29] and long term memory impairment [30]. This evidence concerns the gene EP300 and diabetic cardiomyopathy.