EP300 and diabetic cardiomyopathy: Furthermore, resveratrol suppresses cardiac hypertrophy, cardiac dysfunction, and tissue fibrosis in two different models of muscular dystrophy: dystrophin-deficient mdx mice and δ-sarcoglycan-deficient TO-2 hamsters [65] Acetyltransferase p300 also plays a key role in the pathogenesis of diabetic cardiomyopathy.