The pathology of Parkinson's disease (PD) is primarily characterized by deposition of Lewy bodies and Lewy neurites that contain α-synuclein, highly conserved protein throughout the central (CNS) and peripheral nervous systems (PNS) which leads to the irreversible loss of dopaminergic neurons in the substantia nigra pars compacta and eventual events attributed on the cerebral cortex [79, 80]. Here, SNCA is linked to Parkinson disease.