SOD1 and amyotrophic lateral sclerosis: In a study by Wang et al, they have generated immune-pluripotent stem cells (iPSCs) of ALS patients carrying SOD1+/A272C and FUS+/G1566 heterozygous mutations, implicated as a cause for familial ALS (FALS), and then corrected the aforementioned genes using the CRISPR-Cas9 system [51].