DICER1 and vitelliform macular dystrophy: On the other hand, there was no decline in DICER1 in human RPE cells in other retinal diseases, such as retinitis pigmentosa, vitelliform macular dystrophy and retinal detachment nor was it evident in mouse models of retinal degeneration, suggesting that the DICER1 reduction evident in RPE in GA is not simply a common reaction to retinal injury [32].