For example, a meta-analysis of 69 studies with 4,462 cases and 11,583 controls identified polymorphisms in the TGF-β1 gene to be associated with a higher risk for VaD, microinfarcts, ischemic stroke and cerebral amyloid angiopathy [34, 63, 64]. The gene discussed is TGFB1; the disease is cerebral amyloid angiopathy.