In addition, the CSF of patients with AD, Huntington’s disease (HD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Spinocerebellar ataxia (SCA) and Multiple system atrophy (MSA) shows increased amounts of TGF-β [155, 239, 240]. Here, TGFB1 is linked to Alzheimer disease.