Virally-triggered acute cytokine release of GSCF, IP10, MCP1, MIP1A, IL-2, IL-6, IL-7, and TNF results in pulmonary edema, dysfunction of air-exchange, acute respiratory distress syndrome (ARDS), and acute cardiac injury, and leading to death [30] RAS components were identified in the late 1980s in the adipose tissue and were found to be present both in human and rodent adipose tissue as well as cultured adipocytes [31]. Here, TNF is linked to acute respiratory distress syndrome.