PPARA and acne: According to the etiopathogenesis of acne, potential treatments for acne in the future are topical anti-androgens, melanocortin receptor antagonists, IGF-1 inhibitors, PPAR modulators, acetylcholine inhibitors, topical retinoic and metabolism-blocking agents, monoclonal antibodies, antimicrobial peptides, antioxidants, phosphodiesterase inhibitors, IL-1β inhibitors, vitamin D analogues, dapsone, systemic antiandrogens, and immunotherapy55.