Other genetic causes include autosomal dominant hypocalcemia (ADH), in which an activating mutation of the calcium-sensing receptor (CaSR) decreases its set-point8, and autoimmune polyendocrine syndrome type 1, in which a mutation in the autoimmune regulator gene (AIRE) leads to destruction of the parathyroids and other endocrine glands9. Here, CASR is linked to autoimmune polyendocrine syndrome type 1.