We further detected the effects of NRG-1β on reactive oxygen species (ROS) production in the lipopolysaccharide- (LPS-) stimulated L6 rat skeletal muscle cells with or without the Akt inhibitor MK-2206 in order to determine whether NRG-1β could protect rat skeletal muscle cells against oxidative stress during sepsis and whether this effect could be suppressed by the Akt inhibitor. The gene discussed is AKT1; the disease is Sepsis.