In the present study we analyzed whether polymorphisms rs28366003 in MT2A, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7 and rs2252070 in MMP-13 genes are associated with the risk of breast, lung or colon cancer among polish subjects. This evidence concerns the gene MT2A and malignant colon neoplasm.