Analyses of polymorphisms rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association of tested SNPs with breast, lung and colon cancer risk among polish patients. This evidence concerns the gene MT2A and colonic neoplasm.