The majority of studies claimed ITGB3 acted as a tumor suppressor, due to serials of survival analysis showed ITGB3 highly expressed in OC survivors (Partheen et al., 2008, 2009; Kaur et al., 2009), siITGB3 in SKOV3 increased cell proliferation, migration, and invasive activity (Chen et al., 2009, 2016; Kaur et al., 2009). The gene discussed is ITGB3; the disease is neoplasm.