ITGAL expressed on NK cell (Haspels et al., 2018) and T cell, mediate T cell migration by responding to direct CLL cell-contact induced Rho GTPase signaling suppression (Ramsay et al., 2013) and FAK inhibited ITGA4 activation (Cantor et al., 2015). This evidence concerns the gene ITGA4 and B-cell chronic lymphocytic leukemia.