Additionally, TLR4 can modulate the activation of type I IFN genes through other ways associated with TRIF, where TLR4 interacts with TRIF through TRAM, triggering a late activation of the MYD88 pathway, and the expression of type I IFN genes against viral infection (182, 183) (Figure 3). The gene discussed is TLR4; the disease is viral infectious disease.