Liver-specific Pten deficient mice develop NASH with hepatic steatosis, inflammation and progressive fibrosis, since Pten deficiency induced adipogenic and lipogenic gene expression in hepatocytes and altered glucose metabolism and insulin sensitivity, possibly associated with increased expression of transactivating factors peroxisome proliferator-activated receptor γ (PPARγ) and SREBP1c (26, 47). Here, PTEN is linked to Hepatic steatosis.