Neutralization of OxPLs was effective to ameliorate NASH by decreasing the expression of a variety of inflammatory chemokines and cytokines such as Ccr2, Ccr5, Ccl6, Cx3cr1, Cxcl14, Il1a, reducing recruitment of monocyte-derived macrophages into the liver and promoting shift of Tim4− to Tim4+ macrophages that mediated engulfment of apoptotic cells (147). The gene discussed is TIMD4; the disease is metabolic dysfunction-associated steatohepatitis.