TRAIL-producing NK cells actively promoted the hepatic inflammation with strong cytotoxicity at the early stages of fatty liver disease in the absence of GNMT, suggesting they may contribute to the progression of NASH in the GNMT−/− mice which spontaneously develop steatosis and progress to steatohepatitis, cirrhosis and HCC (48). Here, GNMT is linked to metabolic dysfunction-associated steatohepatitis.