To elucidate the underlying mechanisms of the impaired CD8+ T cell response we had observed in STING KO mice during infection with recombinant MVA, we first analyzed the ability of STING KO and WT bone-marrow-derived dendritic cells (BMDCs) to reactivate CD8+ T cells in vitro in the setting of antigen cross- as well as direct presentation (Supplementary Figures 1B, 3). The gene discussed is CD8A; the disease is infection.