Since plasma cells express a high level of PRDM1 and secrete IL-6, we wanted to know whether PRDM1 and NonO regulate IL-6 in the human myeloma B cell lines, U-266, and RPMI-8226 since both cell lines express a high level of PRDM1 and NonO (Figure S5A). This evidence concerns the gene IL6 and plasma cell myeloma.